The Chemical and Biological Engineering Department is pleased to present our annual Hulburt Memorial Lecture with Jean Tom from Bristol Myers Squibb as part of our ChBE Seminar Series.
Jean Tom will present a seminar titled "Innovations in the Development of Small Molecule Pharmaceuticals."
ABSTRACT: The diverse and complex molecules that are now being discovered and developed in today’s pharmaceutical industry require innovation across multiple dimensions. Innovations in synthetic chemistry and chemical engineering are critical to solving the technical challenges to enable and to scale up new molecular transformations. These innovations are coming about through new strategic approaches in process chemistry and different paradigms of collaborations within a company, across the industry, and at the nexus of industry, academia, and/or government. Advances in high throughput automation, modeling and data science have changed the approach for drug development and are
poised to be even more transformative in the future. The goal of process scientists in a chemical process development organization is to design safe, sustainable, and cost-effective routes to deliver high quality drug substance. These scientists will also need to be the drivers and implementers of innovation approaches to accomplish such goals. How we work, how we develop people, and how we attract talent to the chemical sciences will be paramount to the continued success of modern pharmaceutical industry. This talk will tie together these elements to provide a view on the current state of innovation in the development of complex small molecule pharmaceuticals.
Jean Tom is the Executive Director of Development Engineering, Chemistry Process Development at Bristol Myers Squibb, where she leads a group of chemical engineers focused on development of chemical processes to synthesize small-molecule drug candidates for new therapeutics. Her team generates process knowledge through lab experimentation, modeling and data visualization, and scale-up activities to enable technology and process transfer to manufacturing. Prior to joining BMS in 2006, Jean spent 19 years at Merck Research Laboratories. During that time, she held positions overseeing process development, pilot plant operations and technology transfer, while contributing to new approaches to talent outreach, engagement, and development. She has had a role in 14 pharmaceutical products from Merck and BMS now in the market.
She received B.S. degrees in Chemistry and Chemical Engineering and M.S. degree in Chemical Engineering Practice from MIT. After several years in industry, Jean returned to academia and received a Ph.D. in Chemical Engineering at Princeton University. Jean is active in the AIChE (American Institute of Chemical Engineers) as a Fellow and recipient of the AIChE Industrial Leadership Award (2018), and in the NAE (National Academy of Engineering) to which she was elected to in 2019. She was a founding board member of the Enabling Technologies Consortium (ETC), a consortium of 14 pharmaceutical companies working in the pre-competitive space for technology development. She contributes to the chemical engineering community through her service to ABET, external advisory committees for several departments, AICHE and NAE committees, and through innovative STEM outreach programs.
Bagels and coffee will be provided at 9:30am, and the seminar will start at 9:40am. Please plan to arrive on time to grab a bagel and mingle!
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