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The primary gelatin types used in capsules are typically from bovine or porcine raw materials. Depending on the fill, formulation and on the target market group, manufacturers have flexibility in the raw material type, with some opting for a combination of porcine and bovine options. Bovine bone gelatin, for example, contributes to capsule firmness. Porcine options, on the other hand, offer plasticity and clarity characteristics.
Specifically, hard capsules are made of two cylindrical shells – each closed off at one end. The upper part, called the cap, has a slightly larger diameter than the lower part, called the body. These two parts fit together perfectly to form a hermetically closed unit. Hardcaps are produced before filling with the active ingredient. In a secondary step, contract manufacturers or brand owners are filling the active ingredient or drug in the empty gelatin capsules. As the world's population ages and as we deal with COVID-19, health-minded consumers require dosage formats that are easy to use, easy to swallow and portable.
A standard gelatin hard capsule dissolves in the stomach, under normal conditions, within twenty to thirty minutes after swallowing. Depending on the application, different gelatin types or additional process steps can influence the dissolution process. Some gelatin types dissolve faster than others when they are in contact with acidic fluids and higher temperatures (stomach conditions). For other applications, as for example pain relievers it is necessary to have an even faster dissolving shell. For applications where the drug is targeting the intestines a slower dissolving shell is required.
The primary gelatin types used in capsules are typically from bovine or porcine raw materials. Depending on the fill, formulation and on the target market group, manufacturers have flexibility in the raw material type, with some opting for a combination of porcine and bovine options. Bovine bone gelatin, for example, contributes to capsule firmness. Porcine options, on the other hand, offer plasticity and clarity characteristics.
Like their softgel counterparts, gelatin hard capsules offer value to consumers and producers alike. These advantages are due largely due to their main component, gelatin. Gelatin means "stiff" and is a colorless dry powder that has been used for centuries in a host of food and pharmaceutical uses. For consumers, gelatin dissolves in the human body at normal body temperature, making it the ideal ingredient in hardcaps. While protecting the precious actives inside the capsule against oxygen, light, moisture and dust, the gelatin of the hardcaps affords consumers easy swallowing. Consumers also appreciate that the capsule size and color can help them to more easily identify the respective pharmaceutical drug or nutrient inside. For producers, gelatin provides fast machinability and setting times, ideal dissolution properties and an optimal protection of fill ingredients. Producers can then market the empty hard gelatin capsules to brand owners who are filling with medications or nutrients. And, reputable gelatin suppliers offer Halal and Kosher certifications for different gelatin types to satisfy wide-ranging consumer requirements and preferences. Hard gelatin capsules also allow easy filling.
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