Polyvinylpyrrolidone

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TR8300000

CHEMICAL NAME :

Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.5

CAS REGISTRY NUMBER :

9003-39-8

LAST UPDATED :

199710

DATA ITEMS CITED :

9

WISWESSER LINE NOTATION :

/T5NVTJ AY*1*/

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2500 mg/kg

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - tumors

REFERENCE :

AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2500 mg/kg

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :

AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

8000 mg/kg

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Cardiac - tumors Endocrine - tumors

REFERENCE :

AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,461,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81235 No. of Facilities: 7856 (estimated) No. of Industries: 50 No. of Occupations: 63 No. of Employees: 102100 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7211 No. of Facilities: 7688 (estimated) No. of Industries: 46 No. of Occupations: 63 No. of Employees: 161259 (estimated) No. of Female Employees: 84819 (estimated)